Molecular shrinkage of proteoglycans.
نویسندگان
چکیده
منابع مشابه
Proteoglycans: their structure, interactions and molecular organization in cartilage.
The term ‘proteoglycan’ was introduced in 1967 (see Balazs. 1970) to describe the family of molecules in which glycosaminoglycan chains are linked to protein. However. their rate of diffusion into textbooks of biochemistry has been rather slow, and I will therefore begin this presentation with a general introduction, which I hope will set the basis for their structural identity and indicate how...
متن کاملMatrix proteoglycans: from molecular design to cellular function.
The proteoglycan superfamily now contains more than 30 full-time molecules that fulfill a variety of biological functions. Proteoglycans act as tissue organizers, influence cell growth and the maturation of specialized tissues, play a role as biological filters and modulate growth-factor activities, regulate collagen fibrillogenesis and skin tensile strength, affect tumor cell growth and invasi...
متن کاملProteoglycans of Hyaline Cartilage
Proteoglycan monomers from guinea-pig costal cartilage, bovine nasal and bovine tracheal cartilage were observed in the electron microscope after being spread in a monomolecular layer with cytochrome c. The proteoglycan molecule appeared as an extended central core filament to which side-chain filaments were attached at various intervals. The molecules from the three sources displayed great ult...
متن کاملCartilage proteoglycans.
The predominant proteoglycan present in cartilage is the large chondroitin sulfate proteoglycan 'aggrecan'. Following its secretion, aggrecan self-assembles into a supramolecular structure with as many as 50 monomers bound to a filament of hyaluronan. Aggrecan serves a direct, primary role providing the osmotic resistance necessary for cartilage to resist compressive loads. Other proteoglycans ...
متن کاملProteoglycans of cartilage.
Proteoglycans are probably the most important nonfibrillar constituents of connective tissue although little is known about the proteoglycans of connective tissue other than cartilage. Hence this paper is mainly concerned with cartilage proteoglycans. Proteoglycans are found throughout connective tissue, but those of cartilage have certain features that distinguish them from proteoglycans of ot...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1987
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)47532-1